I like a large base myself, I'm now making a hermitage something around 70x90 tiles.
You can keep most of the infrastructure in one part of the base and dedicate others to animal husbandry (both the animals and fields to feed them), a very large chunk to tree farming, excessive storage etc.
Even a very large base be efficient if you plan the layout properly. - for instance you don't really do much at the tree farm but you'll be spending a lot of time at at the building housing your food and in areas dedicated to food production so it's a good idea to keep them together