When combat is initiated, it locks the original use I had for the 1-5 number keys. For example on 4 I had hearth back to hearthfire, and 5 was lift. I moved them because when I was on combat, the 1-5 keys lose their original use and become combat keys.
I suggest adding in the F1 to F5 (preferably F1 - F10) keys in order to counteract this. Basically, when combat starts, those keys are moved to the f1 - f5 keys OR we could have it so we get another row of keys from the get go. The buttons 6-10 are basically too far away to be used effectively on combat since I have my hand and finger position on the 1-5 keys, making it easier to just move them up over having to move my hand to the other side of the keyboard.