Convenience/QoL
I often carry clovers with me, on the off-chance I'll see a mouflon to shear or an aurochs to milk. I keep it on my hotkey toolbar for convenience, and it's highlighted yellow in my interface. I have accidentally shift-clicked my clover into a compost bin a bunch of times. As a response, I learned to take my clover out of my inventory before filling my compost bin. Which works, but it's annoying, as I have to go get it, and put it back on my hotkey bar each time.
I also often carry a rope with me to use to leash my horse when dismounted. I've lost count of the number of times I've accidentally built said rope into some stationary object I was building. In this latest example it was a potter's wheel.
Suggestion: Don't allow shift-clicking or building-in for items on the hotkey toolbar, much like we can't use them in crafting recipes.