Generally speaking about right-click interaction with objects. If it is small like chest or foragable, and you're moving, rightclicking on the object with cursor over it won't work. You have to put cursor about a tile away from the object in the direction opposite your movement, in other words, you have to predict where object will be in about a second after you click and put cursor in this position to succesfully hit the object. Seems like raycasting(or another method devs are using) is calculated with a delay. This is really annoying, also makes hitting dragonflies really hard. Not sure if this is intended feature against botting but if it is so then it is against players too. If this is going to be fixed i would like to suggest adding the hitboxes for mouse activity, as you can accidentally click beteween two branches of a bush and it wouldn't work again.
Also with the help of custom clients that draw a line from character to the point where he's heading to, you can notice that sometimes character goes not in where the cursor is, but a little bit higher and a little bit on right.